HLA Class II DR Mouse Monoclonal Antibody [Clone ID: TDR31.1]

CAT#: AM31912PU-N

HLA Class II DR mouse monoclonal antibody, clone TDR31.1, Purified

Product Images

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: TDR31.1
• Applications: FC, IHC, WB
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified (With Antibiotics) class II from JY cell line.
• Specificity: Monomorphic class II beta chain epitope.
• Formulation: 50 mM Sodium Phosphate, pH 7.5, 100 mM Potassium Chloride, 150 mM Sodium Chloride, 0.5 mg/ml Gentamicin Sulfate
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Protein A Chromatography
• Background: MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
• Synonyms: HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR