TRBP (TARBP2) Mouse Monoclonal Antibody [Clone ID: 2G10]

CAT#: AM31926PU-N

TRBP (TARBP2) mouse monoclonal antibody, clone 2G10, Purified

Product Images

Western Blot analysis of TARBP2 expression in HeLa nuclear extract using TARBP2 monoclonal antibody, clone 2G10.

• 

  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 2G10
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein
• Specificity: This antibody recognizes Human TARBP2.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Protein A Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens TAR (HIV-1) RNA binding protein 2 (TARBP2), transcript variant 3
• Database Link:
  Entrez Gene 6895 Human
• Background: TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.
• Synonyms: TRBP, TRBP2

Reference Data

• Protein Families: Stem cell - Pluripotency