JNK1 (MAPK8) (318-427) Mouse Monoclonal Antibody [Clone ID: 2F3]

CAT#: AM31930PU-N

JNK1 (MAPK8) (318-427) mouse monoclonal antibody, clone 2F3, Purified


USD 480.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Clone Name 2F3
Applications ELISA, IHC, IP, WB
Recommended Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Immunoprecipitation.
Western Blot: 1/500 - 1/1000.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant protein encoding amino acids 318 to 427 of NP_620637
Specificity This antibody recognizes Human MAPK8 / JNK1 at aa 318-427.
Formulation PBS, pH 7.4
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein A Chromatography
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1
Background JNK1, a MAPK type protein kinase, regulates cell apoptosis, differentiation and growth in response to growth factors, inflammatory cytokines and cellular stress. JNK1 is phosphorylated by MKK4/MAP2K4 and MKK7/MAP2K7. Activated JNK1 translocates to the nucleus where it phosphorylates transcription factors, including c-Jun, ATF2, ELK1, Jun-D and NFAT4. At least four alternatively spliced transcript variants encoding distinct isoforms, 384 and 427 amino acids, have been identified.
Synonyms Mitogen-activated protein kinase 8, c-Jun N-terminal kinase 1, JNK-46, JNK-1, PRKM8
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
Protein Pathways Adipocytokine signaling pathway, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Wnt signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.