PTPRN Mouse Monoclonal Antibody [Clone ID: 8E3]

CAT#: AM31935PU-N

PTPRN mouse monoclonal antibody, clone 8E3, Purified

Product Images

Western Blot analysis of PTPRN expression in transfected 293T cell line by PTPRN monoclonal antibody, clone 8E3.

• 

  Human Pancreas, Islets of Langerhans: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 8E3
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot (Transfected lysate, Recombinant protein).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant protein encoding aa 205-311 of NP_002837
• Specificity: This antibody recognizes Human PTPRN.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction from Ascites
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens protein tyrosine phosphatase, receptor type N (PTPRN), transcript variant 1
• Database Link:
  Entrez Gene 5798 Human
• Background: IA-2, a R8 receptor protein tyrosine phosphatase, is one of the major autoantigens in type 1 diabetes. Autoantibodies against IA-2 have been detected in large numbers newly diagnosed patients with type 1 diabetes and appear to identify a subgroup of prediabetic subjects who rapidly progress to type 1 diabetes; however, IA-2 polymorphisms do not appear to be associated with type 1 diabetes. Three alternative spliced variants of IA-2 have been documented and alternative splicing of IA-2 gene has been suggested to be a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen.
• Synonyms: R-PTP-N, Islet cell antigen 512, ICA512, ICA3, PTP IA-2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Type I diabetes mellitus