Adiponectin (ADIPOQ) Mouse Monoclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, WB |
Recommended Dilution | ELISA: In a Sandwich ELISA (assuming 100 µl/well), a concentration of 2.0-4.0 µg/ml of this antibody will detect at least 500 pg/well of recombinant Human Adiponectin when used in conjunction with compatible detection reagents at a concentration of approximately 0.5-1.0 μg/ml. Western Blot: To detect Human Adiponectin by Western Blot analysis this antibody can be used at a concentration of 1.0-2.0 μg/ml. When used in conjunction with compatible secondary reagents the detection limit for recombinant Human Adiponectin is 0.5-1.0 ng/lane, under reducing conditions and 1.0-2.0 ng/lane, under non-reducing conditions. |
Reactivities | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Hi-5 Insect cells derived Recombinant Human Adiponectin. |
Specificity | This antibody recognizes Adiponectin. |
Formulation | State: Aff - Purified State: Lyophilized purified cell culture |
Purification | Affinity Chromatography Protein A |
Gene Name | Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant 1 |
Database Link | |
Background | Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages) |
Synonyms | ADIPOQ, ACDC, ACRP30, APM1, GBP28 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Type II diabetes mellitus |
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