Tnfrsf1b Rat Monoclonal Antibody [Clone ID: HM102]

CAT#: AM32019PU-N

Tnfrsf1b rat monoclonal antibody, clone HM102, Aff - Purified

Specifications

Product Data

• Clone Name: HM102
• Applications: ELISA, FC, IHC, IP
• Recommended Dilution: Immunoassays.
  Immunoprecipitation.
  Flow Cytometry: Use 1/10 as starting working dilution.
  immunohistochemistry on Frozen Sections: Use 1/10 as starting working dilution.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: The antibody reacts with the extra-cellular part of the Mouse TNF-RII and with the soluble receptor. TNF-RII is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. The TNF-RII molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF-alpha.
  The reactivity of the antibody with soluble TNF-Receptor is not inhibited by high concentrations of Mouse TNF-alpha.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified IgG fraction (≥ 98% pure by SDS PAGE).
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G.
  Product is 0.22 μm Membrane filtered.
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor receptor superfamily, member 1b
• Database Link:
  Entrez Gene 21938 Mouse
• Background: Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are membrane glycoproteins and they are from the family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain.
  TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.
• Synonyms: Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2