CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: CA3]

CAT#: AM32081PU-N

CD41 (ITGA2B) mouse monoclonal antibody, clone CA3, Ig Fraction

Specifications

Product Data

• Clone Name: CA3
• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemical on Frozen Sections.
  Other Immunoassays for cellular and tumor biology.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Partially purified platelet glycoprotein IIb/IIIa complex.
  Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
• Specificity: The antibody clone CA3 reacts with the alpha-IIb-subunit of the beta-integrins.
  Reacts specifically with platelets, megakaryocytes and leukemic cells able to megakaryocytic differentiation.
• Formulation: PBS
  State: Ig Fraction
  State: Liquid Ig fraction
  Stabilizer: 1.0% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 2b
• Database Link:
  Entrez Gene 3674 Human
• Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
  The alpha IIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques.
• Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb