CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: BB10]

CAT#: AM32082PU-N

CD61 (ITGB3) mouse monoclonal antibody, clone BB10, Ig Fraction

Specifications

Product Data

• Clone Name: BB10
• Applications: ELISA, IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemical on Frozen Sections.
  Other Immunoassays for cellular and tumor biology.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Partially purified platelet glycoprotein IIb/IIIa complex
• Specificity: The antibody clone BB10 reacts with beta-3 integrin including the GPIIIa of platelets.
• Formulation: PBS
  State: Ig Fraction
  State: Liquid Ig fraction
  Stabilizer: 1.0% BSA
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit beta 3
• Database Link:
  Entrez Gene 3690 Human
• Background: CD61 also known as gpIIIa, the common ßsubunit (integrin ß3-chain) of the gpIIb/IIIa complex and the vitronectin receptor (VNR). The gpIIb/IIIa complex and the VNR are integrins, ie, a/b-heterodimeric glycoprotein complexes that are involved in cell adhesion. With the CD41 antigen (gpIIb or aIIb), the CD61 antigen forms the gpIIb/IIIa complex, which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin on activated platelets. With the CD51 antigen (VNR a-chain or av), the CD61 antigen forms the VNR, which mediates activation-independent cell adhesion to vitronectin, vWf, fibrinogen, and thrombospondin. The CD61 antigen is found on all normal resting and activated platelets. The CD61 antigen is also found on endothelial cells, megakaryocytes, on some myeloid, erythroid and T-lymphoid leukemic cell lines.
  Beta-3 Integrins contain receptors for vitronectin, fibrinogen, and Von Willebrands factor and, in some instances fibronectin. The aIIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques.
  Monoclonal antibodies against the beta-3 Integrin subunits and the aIIb-Integrin subunit can be used in Immunoblotting, Immunoprecipitation and Immunostaining experiments.
• Synonyms: Integrin beta-3, GP3A, GPIIIa