TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: 52B83]

CAT#: AM32222PU-N

TNF alpha (TNF) mouse monoclonal antibody, clone 52B83, Purified


USD 580.00

2 Weeks*

Size
    • 1 ml

Product Images

Specifications

Product Data
Clone Name 52B83
Applications ELISA, FN, IHC, IP, WB
Recommended Dilution ELISA.
Western Blot.
Flow Cytometry.
Immunohistochemistry on frozen and paraffin sections.
The typical starting working dilution is 1:50. 
Immunoprecipitation. 
Immunoassay. 
Reactivities Guinea Pig, Human, Monkey, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity The monoclonal antibody 52B83 reacts with Tumor Necrosis Factor alpha (TNF-alpha).
The antibody cross reacts with mouse, guinea pig and rhesus monkey TNF-alpha.
Formulation PBS
State: Purified
State: Liquid purified Ig fraction (0.2 um filtered)
Stabilizer: 0.1% BSA
Preservative: 0.02% Sodium azide
Concentration lot specific
Storage

Store the antibody undiluted at 2-8°C.

Stability Shelf life: one year from despatch.

Gene Name tumor necrosis factor
Background

Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17 KD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative micro-organisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of microorganisms and by various cytokines but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intra-cellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-receptors leading to receptor crosslinking. 

Synonyms TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.