CD57 / HNK1 Mouse Monoclonal Antibody [Clone ID: 6-13-19-1]

CAT#: AM32415SU-N

CD57 / HNK1 mouse monoclonal antibody, clone 6-13-19-1, Liquid

Specifications

Product Data

• Clone Name: 6-13-19-1
• Applications: IF, IHC, MC
• Recommended Dilution: Microcytotoxicity.
  Immunofluorescence.
  Recommended Dilutions: Use 1/5 dilution in PBS containing 1% BSA and 0.02% Sodium Azide.
  Positive Control: Peripheral blood lymphocytes.
  Immunohistochemistry on Paraffin Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Jurkat T-cell line
• Specificity: The antibody clone 6-13-19-1 reacts with a 110 kD antigen present on the peripheral blood lymphocyte subset (primarily large granular lymphocytes) identified by the HNK-1 monoclonal antibody. It recognizes part of the Natural Killer cell population. CD57 is furthermore present on cells in neuroectodermal tissue.
• Formulation: State: Liquid
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: Over 100 cell surface markers have been identified through the use of monoclonal antibodies. Many of these markers have proven useful in identifying a specific subpopulation of cells within a mixed colony. Accordingly, these molecules have been assigned a “cluster of differentiation” (CD) designation. T lymphocytes displaying the natural killer (NK) cell marker CD57 (also designated Leu7) on their cell surface are distinguishable from other T cell subsets by their granular lymphocyte morphology and their clonal expansion in patients with AIDS and in recipients of bone marrow transplantation. CD57+ cells have also been shown to localize to sites of certain tumors and large numbers of these cells are detected in the synovial fluid from patients suffering from rheumatoid arthritis.
• Synonyms: HNK-1, LEU7, NK-1, NK-Cell marker, NK1