Cd40 Rat Monoclonal Antibody [Clone ID: FGK45]

CAT#: AM32705AF-N

Cd40 rat monoclonal antibody, clone FGK45, Azide Free

Product Images

BALB/c Mouse splenocytes were stained with a 0.125 ug/106 cells anti-Mouse CD4 Antibody Cat.-No AM32703AF-N (Clone GK1.5) (purple) or Negative Control (green), followed by PE-conjugated Goat anti-Rat Ig (1/200 dilution).

Specifications

Product Data

• Clone Name: FGK45
• Applications: FC, FN
• Recommended Dilution: Flow Cytometry (Cell Surface): 0.125-0.5 μg/10⁶ cells.
  Functional Application: Activates B and NK cells in vivo and in vitro.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
  This Monoclonal antibody FGK45 recognizes Mouse CD40. Other species not tested.
• Formulation: PBS, pH 7.4
  State: Azide Free
  State: Liquid purified IgG fraction
  Preservative: None
• Concentration: 0.5 mg/ml
• Purification: Protein G Chromatography
• Database Link:
  Entrez Gene 21939 Mouse
• Background: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
• Synonyms: TNFRSF5, CDw40, Bp50