Cd8a Rat Monoclonal Antibody [Clone ID: 2.43]

CAT#: AM32706SU-N

Cd8a rat monoclonal antibody, clone 2.43, Ascites

Product Images

Flow Cytometry: BALB/c Mouse splenocytes were stained with a 1/8000 dilution of anti-Mouse CD8 Antibody Cat.-No AM32706SU-N (Clone 2.43) (purple) or negative control (green), followed by PE-conjugated Goat anti-Rat Ig (1/200 dilution).

Specifications

Product Data

• Clone Name: 2.43
• Applications: FC, IF
• Recommended Dilution: In vivo and in vitro Subset Depletion of CD8+ cells.
  FACS.
  Immunofluorescence.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Specificity: Recognizes Mouse CD8a. Other species not tested.
• Formulation: State: Ascites
  State: Liquid Ascites
• Concentration: Approx. 0.5 mg/ml
• Database Link:
  Entrez Gene 12525 Mouse
• Background: The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8, also designated Leu 2 or T8, is a cell surface glycoprotein. It is a two chain complex (αα or αβ) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
• Synonyms: CD8 alpha chain, CD8A, MAL