Cd55 Rat Monoclonal Antibody [Clone ID: 3D5]

CAT#: AM32951FC-N

Cd55 rat monoclonal antibody, clone 3D5, FITC


USD 445.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 3D5
Applications FC, WB
Recommended Dilution Flow Cytometry.
Western blot. 
The typical starting working dilution is 1/50.
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen NRK cells expressing transmembrane-anchored Mouse DAF
Specificity The monoclonal antibody 3D5 recognizes complement decay accelerating factor (DAF), also designated as CD55.
Formulation PBS
Label: FITC
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% BSA
Preservative: 0.02% Sodium Azide
Concentration 0.1 mg/ml
Conjugation FITC
Background Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Mouse DAF (CD55) is a 60 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point.
Synonyms CR; CROM; DAF; TC
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.