RANKL (TNFSF11) (287-304) Rabbit Polyclonal Antibody

CAT#: AM33178PU-S

RANKL (TNFSF11) (287-304) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Human sRANKL synthetic Peptide (EEISIEVSNPSLLDPDQD)
• Specificity: Recognizes Human sRANKL (soluble form). Other species not tested.
• Formulation: 50 mM TRIS pH 7.4
  State: Purified
  State: Lyophilized purified IgG fraction from Serum
• Reconstitution Method: Restore in aqua bidest to 1 mg/ml
• Purification: Protein G Chromatography
• Gene Name: Homo sapiens tumor necrosis factor superfamily member 11 (TNFSF11), transcript variant 1
• Database Link:
  Entrez Gene 8600 Human
• Background: RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.
• Synonyms: OPGL, RANK Ligand, RANKL, TRANCE, TNFSF11, ODF

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction