CD46 Mouse Monoclonal Antibody [Clone ID: 122.2]

CAT#: AM33360PU-T

CD46 mouse monoclonal antibody, clone 122.2, Purified


USD 240.00

2 Weeks*

Size
    • 20 ug

Product Images

Specifications

Product Data
Clone Name 122.2
Applications FC, FN, IF, IHC, IP, WB
Recommended Dilution Functional Assays (Neutralization): Use Azide free Antibody.
Western Blot: 0.5-1 µg/ml. 
Flow Cytometry: 0.5-1 µg/106 cells.
Immunoprecipitation: 1-2 µg/500 µg protein lysate. 
Immunofluorescence: 1-2 µg/ml.
Immunohistochemistry on Frozen Sections: 0.5-1 µg/ml for 30 minutes at RT. 
Recommended Positive Control: HeLa, K-562 or MOLT-4 cells, Kidney.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Human CD46 protein.
Specificity This antibody recognizes Human CD46. Other Species not tested.
Cellular Localization: Cell surface.
Formulation 10mM PBS
State: Purified
State: Liquid purified IgG fraction from Bioreactor Concentrate
Stabilizer: 0.05% BSA
Preservative: 0.05% Sodium Azide
Concentration lot specific
Purification Protein A/G Chromatography
Storage Store undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Predicted Protein Size 56-66 kDa
Gene Name CD46 molecule
Background CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Synonyms TLX, MIC10
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.