Cd80 Hamster Monoclonal Antibody [Clone ID: MAB0713]

CAT#: AM33405PU-N

Cd80 hamster monoclonal antibody, clone MAB0713, Purified

Product Images

Formalin fixed and paraffin embedded mouse tumor section was subjected to immunohistochemistry staining (ABC) of CD80 using (Left panel:x 20; Right panel: x 40)

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  Formalin fixed and paraffin embedded mouse spleen tissue section was subjected to immunohistochemistry staining (ABC) of CD80 using.

Specifications

Product Data

• Clone Name: MAB0713
• Applications: FC, IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/100-1/300.
  Flow Cytometry: 1/100-1/1000.
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant Mouse CD80 protein.
• Specificity: Recognizes Mouse CD80. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Lyophilized purified IgG fraction from Cell Culture Supernatant
  Preservative: None
• Reconstitution Method: Restore with 0.4 ml sterile PBS to a final concentration of 0.5 mg/ml.
• Purification: Affinity Chromatography on Protein A/G
• Database Link:
  Entrez Gene 12519 Mouse
• Background: B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.
• Synonyms: CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1