MMP17 Mouse Monoclonal Antibody [Clone ID: 12N24]

CAT#: AM33485PU-N

MMP17 mouse monoclonal antibody, clone 12N24, Purified

Specifications

Product Data

• Clone Name: 12N24
• Applications: ELISA, NEUT
• Recommended Dilution: ELISA: 1/1000-1/2000.
  Neutralization.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Recombinant Human MMP-17
• Specificity: This antibody recognizes Human MMP-17 by direct ELISA.
• Formulation: Sterile PBS
  State: Purified
  State: Lyophilized purified IgG fraction purified from Cell Culture Supernatant
• Reconstitution Method: Restore the antibody with 0.5 ml sterile PBS and the final concentration is 0.2 mg/ml.
• Purification: Protein G Chromatography
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 4326 Human
• Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage and is known to be expressed in brain, leukocytes, colon, ovary testis and breast cancer as well as in many transformed and non-transformed cell types. The protein exists in two isoforms: a GPI-anchored form and a second secreted form.
• Synonyms: Matrix metalloproteinase-17, MMP17, MT4MMP, Membrane-type matrix metalloproteinase 4