BUB3 Mouse Monoclonal Antibody [Clone ID: AT2H6]
Other products for "BUB3"
Specifications
Product Data | |
Clone Name | AT2H6 |
Applications | ELISA, WB |
Recommended Dilution | The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Recombinant human BUB3 (1-328aa) purified from E. coli. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-A affinity chromatography |
Gene Name | Homo sapiens BUB3, mitotic checkpoint protein (BUB3), transcript variant 1 |
Database Link | |
Background | BUB3 (budding uninhibited by benzimidazoles 3 homolog) is a conserved component of the mitotic spindle assembly complex (MCC). It contains five WD repeat domains and forms cell cycle constitutive complexes with BUB1 and BUBR1. BUB3 is essential for the kinetochore localization of BUB1 and BUBR1. As a component of the MCC, BUB3 is involved in the essential spindle checkpoint pathway that operates during early embryogenesis. The spindle checkpoint pathway functions to postpone the initiation of anaphase until chromosomes are properly attached to the spindle. This acts to ensure accurate chromosome segregation. In addition, BUB3 plays a role in regulating the establishment of correct kinetochore-microtubule attachments. |
Synonyms | BUB3L; hBUB3 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle |
Documents
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