GRP78 (HSPA5) Mouse Monoclonal Antibody [Clone ID: AT3D2]

CAT#: AM50344PU-S

GRP78 (HSPA5) mouse monoclonal antibody, clone AT3D2, Purified


USD 230.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Clone Name AT3D2
Applications ELISA, WB
Recommended Dilution The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human BIP (20-650aa) purified from Baculo virus.
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens heat shock protein family A (Hsp70) member 5 (HSPA5)
Background Binding immunoglobulin protein (BIP) also known as 78kDa glucose-regulated protein(GRP-78) or heat shock 70kDa protein 5(HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum(ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BIP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BIP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER.
Synonyms 78 kDa glucose-regulated protein, Heat shock 70 kDa protein 5, BiP
Reference Data
Protein Families Druggable Genome
Protein Pathways Antigen processing and presentation, Prion diseases

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.