SIGLEC10 Mouse Monoclonal Antibody [Clone ID: 5G6]

CAT#: AM60044RP-N

SIGLEC10 mouse monoclonal antibody, clone 5G6, PE, Purified

Product Images

Human peripheral blood lymphocytes stained with A: mouse anti-human SIGLEC10 Cat.-No. AM60044RP-N or B the corresponding isotype control; dual stained with mouse anti-human CD19-APC Cat.-No. SM1529APC

Specifications

Product Data

• Clone Name: 5G6
• Applications: FC
• Recommended Dilution: Flow cytometry: Neat , use 10ul of the suggested working dilution to label 10e6 cells.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human SIGLEC10, fused with the Fc region of human IgG
• Specificity: This antibody clone 5G6 specifically recognizes human SIGLEC10.
  Studies have shown that clone 5G6 does not cross react with SIGLECs 3, 5, 7, 8 and 9 (Munday J. et al.)
• Formulation: PBS containing 0.09% Sodium azide, 1% BSA and 5% Sucrose
  Label: PE
  State: Purified
  State: Lyophilized purified IgG
  Label: R. Phycoerythrin
• Reconstitution Method: Restore with 1 ml distilled water.
• Purification: Affinity chromatography on Protein G
• Conjugation: PE
• Database Link:
  Entrez Gene 89790 Human
• Background: Siglec10 (Sialic acid binding Ig like lectin 10), a putative adhesion molecule and member of the Ig superfamily, is expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16⁺CD56^- natural killer (NK) cells.
  Structurally, Siglec10 is most similar to the CD33 related group of Siglecs, and preferentially binds to glycoconjugates containing alpha 2,3 or alpha2,6 linked sialic acid. Studies have shown that Siglec10 acts as a substrate for VAP1 (Vascular adhesion protein1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking (Kive, E. et al.). This interaction between Siglec10 and VAP1, implicates Siglec10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment.
• Synonyms: Siglec-10, SLG2