Mapk8ip2 (226-421) Mouse Monoclonal Antibody [Clone ID: S135-37]

CAT#: AM60064PU-N

Mapk8ip2 (226-421) mouse monoclonal antibody, clone S135-37, Purified

Specifications

Product Data

• Clone Name: S135-37
• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/1000; 1 μg/ml was sufficient for detection of JIP-2 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody.
  Immunocytochemistry.
  Immunohistochemistry: Free floating sections, fixed in formaldehyde.
• Reactivities: Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 226-421 of mouse JIP-2 (Accession no. Q9ERE9); >50% identity with JIP-1.
• Specificity: This antibody detects a 100 kDa and larger protein.
  Does not cross-react with JIP-1.
• Formulation: PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Protein G chromatography
• Database Link:
  Entrez Gene 60597 Mouse
• Background: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It is expressed mainly in the cerebellum, pituitary gland, occipital lobe, and the amygdala of the brain, but also in the pancreas, including insulin-secreting cells.
• Synonyms: JNK-interacting protein 2, MAPK8IP2, IB2, JIP2, PRKM8IPL, JIP2, Islet-brain-2