Aromatase (CYP19A1) Rabbit Polyclonal Antibody

CAT#: AP00001PU-N

Aromatase (CYP19A1) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of Aromatase in Human brain cell lysate using anti-Aromatase antibody.

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  Immunohistochemical staining of human placenta using Aromatase antibody showed staining of trophoblasts (Placental Villi 40X).

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  Immunohistochemical staining of human testis using Aromatase antibody showed staining of Leydig cells and spermatocytes in seminiferous tubules (Testis, Leydig Cells 60X).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry (10 µg/ml).
  Western blotting (0.5-4 µg/ml). A 55 kDa band can be detected, corresponding to the expected Molecular Weight of Aromatase, an additional 35 kDa band (believed to be the cleavage product of Aromatase) can also be detected in Jurkat cells.
• Reactivities: Bovine, Chicken, Equine, Human, Mouse, Porcine, Rabbit, Rat, Sheep
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surronding amino acid 385 of Human Aromatase
• Specificity: This antibody recognizes Aromatase p450AROM.
• Formulation: PBS containing 30% Glycerol, 0.5% BSA, 5mM EDTA and 0.01% Thimerosal as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store (in aliquots) at -20°C to -80°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cytochrome P450 family 19 subfamily A member 1
• Database Link:
  Entrez Gene 1588 Human
• Background: Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.
• Synonyms: Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19