cIAP1 (BIRC2) Rabbit Polyclonal Antibody

CAT#: AP00060PU-N

cIAP1 (BIRC2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of cIAP-1 in Jurkat cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml.
  Immunohistochemistry: 5 µg/ml.
  Jurkat cell lysate and Rat kidney tissue lysate can be used as positive controls.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 530 of human cIAP-1
• Specificity: This antibody detects cIAP-1.
• Formulation: PBS, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens baculoviral IAP repeat containing 2 (BIRC2), transcript variant 1
• Database Link:
  Entrez Gene 11797 MouseEntrez Gene 60371 RatEntrez Gene 329 Human
• Background: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and -7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.
• Synonyms: API1, MIHB, RNF48, Inhibitor of apoptosis protein 2, C-IAP1, cIAP1, IAP homolog B, HIAP2, HIAP-2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis