Caspase 9 (CASP9) Rabbit Polyclonal Antibody
Other products for "CASP9"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western Blot: 0.5-4.0 µg/ml. Mouse small intestine and rat kidney tissue lysates can be used as Positive Controls. |
Reactivities | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide surrounding amino acid 345 of Mouse Caspase-9 |
Specificity | The antibody detects 45 kDa procaspase-9, 35/37 kDa cleaved large fragment and the 25 kDa fully cleaved Caspase-9. |
Formulation | PBS, pH 7.2, containing 30% Glycerol, 0.5% BSA and 0.01% Thimerosal. State: Aff - Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Purification | Protein A Chromatography. |
Storage | Store the antibody undiluted at -20°C or (in aliquots) at -70°C for long term storage. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens caspase 9 (CASP9), transcript variant alpha |
Database Link | |
Background | Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase- 9/Apaf-1. The complex processes procaspase-9 into a large subunit (35 kDa or 17 kDa) and small (10 kDa) by self-cleavage at D315. Activated caspase-9 further cleaves other caspase members including caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. In addition to self-cleavage, procaspase-9 can also be cleaved in vivo by caspase-3 at D330. The process served as a positive feedback to amplify the apoptotic signal in caspase activation pathway. |
Synonyms | CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3 |
Reference Data | |
Protein Families | Druggable Genome, Protease, Stem cell - Pluripotency |
Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis |
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