MEK4 (MAP2K4) pSer80 Rabbit Polyclonal Antibody

CAT#: AP00207PU-N

MEK4 (MAP2K4) pSer80 rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-4 μg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding Ser80 of human SEK1/MKK4.
• Specificity: The antibody recognizes phosphorylated SEK1/MKK4/JKK1.
• Formulation: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Peptide affinity purified
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 6416 Human
• Background: SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stress-activated signal transduction.
• Synonyms: JNK-activating kinase 1, MAP Kinase Kinase 4, SAPK/ERK kinase 1, PRKMK4, SERK1, MEK-4, MAPKK4, MKK4