COX4 (COX4I1) Rabbit Polyclonal Antibody

CAT#: AP00293PU-N

COX4 (COX4I1) rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Western blot analysis of Cox-4 expression in Jurkat cell lysate (Lane 1), and mouse small intestine tissue lysate (Lane 2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml.
  Immunohistochemistry: 10-20 μg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 32 of human Cox IV.
• Specificity: The antibody detects 36 kDa annexin VIII. The ~28-30 kDa cleavage fragments can also be detected in Jurkat cell lysate.
  Blocking peptide is available separately (AP00292CP-N).
• Formulation: PBS, pH 7.2 containing 30% glycerol, 0.5% BSA as stabilizer and 0.01% thimerosal as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Affinity Chromatography.
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cytochrome c oxidase subunit 4I1 (COX4I1), transcript variant 1
• Database Link:
  Entrez Gene 1327 Human
• Background: Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduction of dioxygen to water in the electron transport chain. The three core catalytic units COX-1, -2, -3 are trans-membrane proteins encoded by the mitochondrial genome, whereas the remaining 10 subunits are nuclear encoded and expressed in a tissue-specific manner. The expression of nuclear and mitochondrial subunits of the mitochondrial respiratory chain is thought to be highly coordinated. Cox-4 is believed to regulate COX activity according to the extramitochondrial ATP/ADP ratio.
• Synonyms: Cytochrome c oxidase polypeptide IV, COX IV-1, COX4I1, COX4

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease