LRP5 + LRP6 Rabbit Polyclonal Antibody

CAT#: AP00345PU-N

LRP5 + LRP6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of LRP-5/6 with Jurkat cell lysate (Lane 1: 100 g; Lane 2: 50 g).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 0.5-4.0 µg/ml.
  Jurkat cell lysate can be used as a Positive Control.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 437 of Human LRP.
• Specificity: The antibody recognizes the ~170 kDa full length LRP-5/6.
  A cleavage fragment (~120 kDa) can also be detected.
• Formulation: PBS containing 30% Glycerol, 0.5% BSA and 0.01% Thimerosal as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity Chromatography
• Background: LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Want signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta-catenin stabilization.
• Synonyms: LRP5, LRP7, Low-density lipoprotein receptor-related protein 5, LRP6, Low-density lipoprotein receptor-related protein 6
• Note: Blocking Peptide (AP00345CP-N) is also available separately.