PDE1A Rabbit Polyclonal Antibody

CAT#: AP00651SU-N

PDE1A rabbit polyclonal antibody, Serum

Product Images

Figure 1: Western blot using anti-PDE1A antibody (1:20,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western blot (1/2000 as a guideline).
  Immunoprecipitation.
  Immunohistochemistry.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Designed from the C-terminal region common to all known 1A isoforms.
• Specificity: The antibody selectively detects proteins corresponding to the PDE1A sub-family (See Figure 1).
• Formulation: PBS containing 0.05% Sodium Azide as preservative
  State: Serum
  State: Liquid Diluted Serum
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -80°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 61 kDa (Predicted)
• Database Link:
  Entrez Gene 5136 Human
• Background: Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.
  PDE1 has three subtypes, PDE1A, PDE1B and PDE1C. PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP.
• Synonyms: Phosphodiesterase 1A, Phosphodiesterase-1A calmodulin-dependent, Cam-PDE 1A, HSPDE1A, HCAM1, hCam-1