Glucagon Receptor (GCGR) Rabbit Polyclonal Antibody

CAT#: AP01269PU-N

Glucagon Receptor (GCGR) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Glucagon Receptor antibody at 1/500 dilution Lane 1: HEK293T whole cell lysate Lane 2: Raw264.7 whole cell lysate Lane 3: H9C2 whole cell lysate.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 100-150 of Human Glucagon Receptor.
• Specificity: This antibody detects endogenous levels of Glucagon Receptor protein. (region surrounding Lys136)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 15mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~54 kDa
• Gene Name: glucagon receptor
• Database Link:
  Entrez Gene 14527 MouseEntrez Gene 24953 RatEntrez Gene 2642 Human
  UniProt ID P47871
• Background: Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The 56 GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.
• Synonyms: GCGR, GL-R

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction