Histone H2A.X (H2AFX) Rabbit Polyclonal Antibody
Other products for "H2AFX"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200 Immunohistochemistry on Paraffin sections: 1/50-1/200. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 100-150 of Human Histone H2A.X. |
Specificity | This antibody detects endogenous levels of Histone H2A.X protein (region surrounding Lys128). |
Formulation | Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 15 kDa |
Gene Name | Homo sapiens H2A histone family member X (H2AFX) |
Database Link | |
Background | H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability. |
Synonyms | H2a/x, H2AFX, H2AX |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Systemic lupus erythematosus |
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