CXCR4 Rabbit Polyclonal Antibody
Other products for "CXCR4"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 310-360 of Human CXCR-4. |
Specificity | CXCR-4 (V340) pAb detects endogenous levels of CXCR-4 protein. |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Predicted Protein Size | ~40 kDa |
Gene Name | Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1 |
Database Link | |
Background | The C-X-C or alpha chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (variously referred to as LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major coreceptor for T-tropic HIV-1 and SDF-1 has been shown to inhibit HIV-1 infection. |
Synonyms | CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
Protein Pathways | Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.