Frizzled 7 (FZD7) Rabbit Polyclonal Antibody

CAT#: AP01299PU-N

Frizzled 7 (FZD7) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Frizzled-7 antibody in extracts from HT-29 cells.

Specifications

Product Data

• Applications: ELISA, IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 61-110 of Human Frizzled-7.
• Specificity: This antibody detects endogenous levels of Frizzled-7 protein. (region surrounding Tyr87)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography.
• Predicted Protein Size: ~ 64, 85 kDa
• Database Link:
  Entrez Gene 8324 Human
• Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins: FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt. frizzled-7 has a Lys-Thr-X-X-X-Trp motif which is involved in the activation of the Wnt/beta-catenin signaling pathway. frizzled-7 is an integral membrane protein showing a high expression in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain and placenta. It is specifically expressed in squamous cell esophageal carcinomas.
• Synonyms: Fz-7, mFz7