Frizzled 9 (FZD9) Rabbit Polyclonal Antibody

CAT#: AP01300PU-N

Frizzled 9 (FZD9) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Frizzled-9 antibody in extracts from HUVEC cells.

Specifications

Product Data

• Applications: ELISA, IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 571-620 of Human Frizzled-9.
• Specificity: Frizzled-9 antibody detects endogenous levels of Frizzled-9 protein. (region surrounding Leu591)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography
• Predicted Protein Size: ~ 64 kDa
• Database Link:
  Entrez Gene 8326 Human
• Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic β-catenin accumulation. In rat, frizzled-9 is important in Wnt/β-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
• Synonyms: Fz-9, hFz9