MCSF Receptor (CSF1R) Rabbit Polyclonal Antibody

CAT#: AP01353PU-N

MCSF Receptor (CSF1R) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of c-Fms antibody (Cat.-No.: AP01353PU-N) at 1/500 dilution Lane 1:MCF-7 cell lysate Lane 2:sp2/0 cell lysate Lane 3:Rat liver tissue lysate

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  Immunohistochemistry (IHC) analyzes of CSFR antibody (Cat.-No.: AP01353PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 771-820 of Human c-Fms.
• Specificity: This antibody detects endogenous levels of CSFR protein (region surrounding asn805)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 92, 108 kDa
• Gene Name: Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 1
• Database Link:
  Entrez Gene 12978 MouseEntrez Gene 1436 Human
• Background: c-Fms/CSF-1R is a transmembrane tyrosine kinase receptor belonging to the CSF1/PDGF receptor family. It is encoded by the c-Fms proto-oncogene and is expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells and some myoblasts. It is important for growth and differentiation of myeloid cells and its function can be regulated by SLAP-2. c-Fms/CSF-1R is responsible for mediating all of the functions of M-CSF. M-CSF is a glycoprotein required for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF has also been identified as an important mediator of the inflammatory response and can regulate the release of proinflammatory cytokines from macrophages.
• Synonyms: CSF-1-R, Fms proto-oncogene, c-fms, CSF1R, FMS, Macrophage colony-stimulating factor 1 receptor

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer