GRK1 Rabbit Polyclonal Antibody

CAT#: AP01451PU-N

GRK1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of GRK1 antibody (Cat.-No.: AP01451PU-N) in extracts from HUVEC cells.

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  Immunohistochemistry (IHC) analyzes of GRK1 antibody (Cat.-No.: AP01451PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: GRK1 antibody detects endogenous levels of GRK1 protein. (region surrounding Ala17)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Predicted Protein Size: ~ 63 kDa
• Gene Name: Homo sapiens G protein-coupled receptor kinase 1 (GRK1)
• Database Link:
  Entrez Gene 24013 MouseEntrez Gene 81760 RatEntrez Gene 6011 Human
• Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
• Synonyms: GRK1, RHOK, G protein-coupled receptor kinase 1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Endocytosis