TGF beta Receptor I (TGFBR1) Rabbit Polyclonal Antibody

CAT#: AP01457PU-N

TGF beta Receptor I (TGFBR1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of TGFβ RI Antibody at 1/500 dilution. Lane 1: Hela whole cell lysate. Lane 2: LO2 whole cell lysate. Lane 3: Raw264.7 whole cell lysate. Lane 4: Mouse kidney tissue lysate. Lane 5: Rat heat tissue lysate.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human TGFβ RI.
• Specificity: This antibody detects endogenous levels of TGFβ RI protein (region surrounding Glu161).
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 15 mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 55 kDa
• Database Link:
  Entrez Gene 7046 Human
• Background: Three members of the TGF beta family, TGF beta 1, TGF beta 2 and TGF beta 3, are known in mammals. TGF betas mediate their activity by high affinity binding to the type 2 receptor, which requires both its kinase activity and association with members of a series of related type 1 receptors called activin receptor like kinase (ALK) 1 to 6. Of these, only ALK5 has been shown to represent a functional TGF beta type 1 receptor, but only ALK2 and ALK4 bind activin with high affinity. TGF beta R3 binds TGF beta and retains TGF beta for presentation to the signaling receptors.
• Synonyms: TGF-beta receptor type-1, TGF-beta type I receptor, TbetaR-I, TGFR-1, ALK5, SKR4