FUBP3 Rabbit Polyclonal Antibody

CAT#: AP01471PU-N

FUBP3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of FBP3 antibody in extracts from COLO cells.

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  Immunohistochemistry analysis of FBP3 antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 210-254 of Human FBP3.
• Specificity: This antibody detects endogenous levels of FBP3 protein. (region surrounding Arg241)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~60 kDa
• Gene Name: Homo sapiens far upstream element (FUSE) binding protein 3 (FUBP3)
• Database Link:
  Entrez Gene 320267 MouseEntrez Gene 362106 RatEntrez Gene 8939 Human
• Background: Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxylterminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
• Synonyms: FBP3, FUSE-binding protein 3