Collagen XVII (COL17A1) (507-548) Rabbit Polyclonal Antibody

CAT#: AP02251PU-N

Collagen XVII (COL17A1) (507-548) rabbit polyclonal antibody, Purified


USD 560.00

2 Weeks*

Size
    • 100 ug

Product Images

Other products for "COL17A1"

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA: 1/5000.
Western blot: 1/500 (Ref.2) 
Immunocytochemistry (Ref.3). 
Immunocytochemistry on Frozen Sections: 1/100 (Ref.3).
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Glutathione-S-transferase fusion protein containing the sequence of the immunodominant region of human type XVII collagen / BP180 (aa 507-548)
Specificity This antibody detects Human type XVII Collagen / BP180 (aa 507-548).
Formulation 50mM Tris, pH 7.4
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore in aqua bidest to a concentration of 1 mg/ml.
Purification Protein G Chromatography
Storage Store lyophilized at 2-8°C and reconstituted at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Gene Name Homo sapiens collagen type XVII alpha 1 chain (COL17A1)
Background Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.
Synonyms COL17A1, BP180, BPAG2, Bullous pemphigoid antigen 2, LAD-1, LABD97
Reference Data
Protein Families Transmembrane

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.