uPA (PLAU) Goat Polyclonal Antibody

CAT#: AP02255SU-S

uPA (PLAU) goat polyclonal antibody, Serum


USD 125.00

2 Weeks*

Size
    • 20 ul

Product Images

Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution ELISA.
Immunohistochemistry on Frozen sections: 1/50-1/100.
Immunohistochemistry on Paraffin sections: 1/50 (Pretreatment with 0.05% Pronase E for 20 minutes).
Reactivities Human
Host Goat
Clonality Polyclonal
Immunogen Purified human Urokinase plasminogen activator [uPA]
Specificity This antibody detects Urokinase plasminogen activator.
No cross reactivities obtained with tPA and PAI-2.
Formulation State: Serum
State: Lyophilized serum.
Reconstitution Method Restore in aqua bidest to initial volume.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Urokinase is a serine protease involved in degradation of the extracellular matrix and pos- sibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor.
Synonyms Urokinase-type plasminogen activator, U-plasminogen activator, Urokinase
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.