Phosphoserine Rabbit Polyclonal Antibody

CAT#: AP03033HR-N

Phosphoserine rabbit polyclonal antibody, HRP, Aff - Purified


USD 490.00

5 Days*

Size
    • 400 ul

Product Images

Specifications

Product Data
Applications ELISA, WB
Recommended Dilution ELISA: 1/1000. 
Western blot: 1/500.
2 μg/mL of this antibody was sufficient for detection of phosphorylation signal in western blot analysis using Human MMRU cells treated with 0.1 μM Okadaic Acid.
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Phosphoserine conjugated to KLH
Specificity This antibody recognizes proteins phosphorylated on Serine residues.
Does not cross-react with Phosphotyrosine.
Formulation PBS, pH 7.0
Label: HRP
State: Aff - Purified
State: Liquid purified Ig fraction
Stabilizer: 0.1% BSA, 50% Glycerol
Preservative: 0.01% Proclin150
Concentration lot specific
Purification Affinity Chromatography
Conjugation HRP
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Background Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1).
Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.