p53 (TP53) Sheep Polyclonal Antibody

CAT#: AP05006PU-N

p53 (TP53) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

Product Images

Specifications

Product Data
Applications IHC, IP, WB
Recommended Dilution WB: 1-10 µg/ml. 
Immunoprecipitation.
Immunohistochemistry on formalin-fixed and paraffin embedded tissue.
Reactivities Human, Mouse, Rat
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen GST p53 fusion protein containing amino acids 1-393 of human p53.
Specificity This antibody reacts to GST p53.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig (0.2µm sterile filtered)
Concentration lot specific
Purification Ammonium Sulfate Precipitation
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background GST p53 fusion protein containing amino acids 1-393 of human p53was used as immunogen. p53 has a molecular weight of 53kDa p53 is a transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein.
Synonyms Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.