Dab1 (N-term) Sheep Polyclonal Antibody

CAT#: AP05070PU-N

Dab1 (N-term) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

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Specifications

Product Data
Applications WB
Recommended Dilution Western Blot: 1-5 μg/ml.
Immunoprecipitation: 5-10 μg/ml.
Positive Control: 293 cells transfected with Dab-1 HA tag.
Reactivities Mouse
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein corresponding to amino acids 1-179 of Mouse disabled coupled to a GST fusion protein.
Specificity This antibody recognizes Mouse DAB1 (Disabled 1) (N-term). Other species not tested.
Formulation PBS
State: Purified
State: Liquid purified Ig (0.2mm sterile filtered)
Preservative: 0.08% Sodium Azide
Concentration Lot specific
Purification Ammonium Sulfate Precipitation
Gene Name Mus musculus disabled 1 (Dab1), transcript variant 1
Background Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.
Synonyms Disabled homolog 1
Reference Data

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