Dab1 (N-term) Sheep Polyclonal Antibody
Other products for "Dab1"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western Blot: 1-5 μg/ml. Immunoprecipitation: 5-10 μg/ml. Positive Control: 293 cells transfected with Dab-1 HA tag. |
Reactivities | Mouse |
Host | Sheep |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein corresponding to amino acids 1-179 of Mouse disabled coupled to a GST fusion protein. |
Specificity | This antibody recognizes Mouse DAB1 (Disabled 1) (N-term). Other species not tested. |
Formulation | PBS State: Purified State: Liquid purified Ig (0.2mm sterile filtered) Preservative: 0.08% Sodium Azide |
Concentration | Lot specific |
Purification | Ammonium Sulfate Precipitation |
Gene Name | Mus musculus disabled 1 (Dab1), transcript variant 1 |
Database Link | |
Background | Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway. |
Synonyms | Disabled homolog 1 |
Reference Data |
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