ACVR1 Sheep Polyclonal Antibody

CAT#: AP05119PU-N

ACVR1 sheep polyclonal antibody, Purified

Product Images

Western blot using ALK-2 antibody on ALK-2 fusion protein.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western Blot: 5 - 10 µg/ml.
  Immunoprecipitation: 5 µg/mg of protein lysate.
  Immunohistochemistry on paraffin sections: 5 - 10 µg/ml.
• Reactivities: Chicken
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.
• Specificity: This antibody reacts to ALK2.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: Lot specific
• Gene Name: activin A receptor, type I
• Database Link:
  Entrez Gene 395246 Chicken
• Background: Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor-beta (TGF-beta). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. It also induces the Tlx2 promoter in the absense of BMP7.
• Synonyms: Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A