EDG4 (LPAR2) Rabbit Polyclonal Antibody

CAT#: AP05151PU-N

EDG4 (LPAR2) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis using EDG4/LPA2 (NT) antibody at 5 ug/ml on RH7777 cells transfected with EDG4/LPA2 protein in the absense (1) and presense (2) of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 5-10 µg/ml.
  Should be visualized using a high sensitivity secondary/substrate system.
  Positive Control: RH7777 cells transfected with EDG4 protein.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Antibody raised against a unique synthetic peptide derived from the N-terminal of the Human EDG4 protein.
• Specificity: This antibody recognizes Human EDG-4 / LPA2. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.08% Sodium Azide
• Concentration: Lot specific
• Purification: Ammonium Sulfate Precipitation
• Database Link:
  Entrez Gene 9170 Human
• Background: EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.
• Synonyms: EDG4, LPAR2, Ipa-2