Sphingomyelin Synthase 2 (SGMS2) Rabbit Polyclonal Antibody

CAT#: AP05208PU-N

Sphingomyelin Synthase 2 (SGMS2) rabbit polyclonal antibody, Purified

Product Images

Western blot on human brain lysate (10 ug/lane) using antibody to Sphingomyelin Synthase 2 (0.5 ug/ml). Lane A] 1 ug/ml antibody alone, lane B] antibody plus 3 ug blocking peptide. Blot was developed with Pierce's Super Sytem West Femto - 1 minute exposure.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA.
  Western Blot: 5 - 10 µg/ml.
  Positive Control: Brain, heart, kidney, liver, muscle and stomach.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the human sphingomyelin synthase 2 protein.
• Specificity: This antibody reacts to Sphingomyelin Synthase 2.
• Formulation: Phosphate buffered saline, pH 7.4
  State: Purified
  State: Liquid purified Ig
• Concentration: Lot specific
• Gene Name: Homo sapiens sphingomyelin synthase 2 (SGMS2), transcript variant 2
• Database Link:
  Entrez Gene 166929 Human
• Background: Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine and then onto ceramide. This also yields diacylglycerol as a side product. The reaction is catalysed by SM synthase, an important enzyme in the regulation of diacylglycerol and ceramide as anti- and proapoptotic stimuli. SM synthesis occurs in the lumen of the Golgi as well as on or at the cell surface. It is uncertain which SM enzyme forms are present at these differnet cellular locations. Human, mouse and Caenorhabditis elegans genomes each contain at least two different SM synthase (SMS) genes. Human SMS1 is localised to the Golgi, SMS2 resides primarily at the plasma membrane.
• Synonyms: Sphingomyelin synthase 2, SMS2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism