SPHK2 (Long Form) Rabbit Polyclonal Antibody
Product Images
Other products for "SPHK2"
Specifications
Product Data | |
Applications | ELISA, WB |
Recommended Dilution | ELISA. Western blot: 1 - 5 µg/ml. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from the N-terminal extension of the Sphk2-L protein. |
Specificity | This antibody reacts to Sphingosine Kinase 2 (Long Form). |
Formulation | Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig |
Concentration | Lot specific |
Gene Name | Homo sapiens sphingosine kinase 2 (SPHK2), transcript variant 1 |
Database Link | |
Background | The long form of sphingosine kinase 2 (Sphk2-L) is a speciesspecific isoform of the Sphk2 enzyme expressed in human but not in mouse. It is an N-terminal extended form of Sphk2, extended by 36 amino acids. It functions as expected, catalyzing the formation of sphingosine 1-phosphate from sphingosine, however it appears to have a decreased ability to inhibit DNA synthesis as compared to Sphk2-S (short form of Sphk2). Under normal cellular conditions, Sphk2-L does not appear to inhibit DNA synthesis, but under serum deprivation, SphK2-L translocates to the nucleus and accumlates. This accumlation may be involved in the cessation of cell proliferation or apoptosis depending on the cell type. |
Synonyms | SK2, SPHK2 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Metabolic pathways, Sphingolipid metabolism, VEGF signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.