MD1 (LY86) Rabbit Polyclonal Antibody

CAT#: AP05223PU-N

MD1 (LY86) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0,5 - 1 µg/ml.
  May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficie nt CD180 cell surface expression.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal MD-1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human MD-1
• Specificity: This antibody reacts to Lymphocyte Antigen 86/MD-1.
• Formulation: Phosphate buffered saline with 0.02% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: Lot specific
• Gene Name: Homo sapiens lymphocyte antigen 86 (LY86)
• Database Link:
  Entrez Gene 9450 Human
• Background: Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway.. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
• Synonyms: Lymphocyte antigen 86, MD1

Reference Data

• Protein Families: Secreted Protein