SPTLC1 Rabbit Polyclonal Antibody

CAT#: AP05280PU-N

SPTLC1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot on human kidney lysate (10 ug/lane) using Serine Palmitoyltransferase 1 antibody at 1 ug/ml. Blot was developed using anti rabbit HRP at 1:75k and Supersignal West Femto. Exposure was 2 minutes.

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  Immunohistochemical staining of normal Human lung tissue with Serine Palmitoyltransferase 1 antibody at 15 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: (1-5 µg/ml).
  Immunohistochemistry: (5-10 µg/ml).
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the Human Sserine Palmitoyltransferase enzyme
• Specificity: This antibody detects Serine Palmitoyltransferase 1, ubiquitously expressed.
• Formulation: Phosphate buffered saline with 0.08% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: Lot specific
• Purification: Antigen Immunoaffinity Chromatography
• Predicted Protein Size: 52.7 kDa
• Gene Name: Homo sapiens serine palmitoyltransferase long chain base subunit 1 (SPTLC1), transcript variant 1
• Database Link:
  Entrez Gene 10558 Human
• Background: Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells. Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract. Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.
• Synonyms: Serine palmitoyltransferase 1, SPT 1, SPT1, LCB 1, LCB1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism