Smoothened (SMO) Rabbit Polyclonal Antibody

CAT#: AP05293SU-N

Smoothened (SMO) rabbit polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution Western blot (1-5 µg/ml).
Positive control: brain.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide derived from the human SMO protein
Specificity This antibody detects SMO (Smoothened Homolog).
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified IG fraction
Concentration lot specific
Storage Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Gene Name Homo sapiens smoothened, frizzled class receptor (SMO)
Background SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.
Synonyms SMOH, Smoothened homolog
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.