Complement C4A (C4A) Rabbit Polyclonal Antibody

CAT#: AP05369PU-N

Complement C4A (C4A) rabbit polyclonal antibody, Purified


USD 1,155.00

5 Days*

Size
    • 250 ul

Product Images

Specifications

Product Data
Applications IF, IHC
Recommended Dilution Immunohistochemistry on frozen sections: 1/20 - 1/80.
Immunohistochemistry on paraffin sections: 1/20 - 1/80; Heat induced epitope retrieval is recommended.
Immunofluorescence: 1/20 - 1/80.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 1241-1256 of C4 conjugated to Keyhole limpet Haemocyanin.
Specificity This antibody is specific for complement split product C4d.
Formulation Phosphate buffered saline containing 0.09% Sodium Azide (NaN3)
State: Purified
State: Liquid purified IgG
Concentration lot specific
Purification Affinity chromatography on Protein G
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens complement component 4A (Rodgers blood group) (C4A), transcript variant 1
Background C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
Synonyms Complement Component 4, CPAMD2, CPAMD3
Reference Data
Protein Pathways Complement and coagulation cascades, Systemic lupus erythematosus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.